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Melanogenesis Associated Transcription Factor (MITF) Antibody
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Catalogue No: abx026323
Price:
US$326.25
(Size: 80 µl)
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This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Research Articles on Melanogenesis Associated Transcription Factor (MITF)
| Target | Melanogenesis Associated Transcription Factor (MITF) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC: 1/800, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1-28 amino acids from the N-terminal region of human MITF. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O75030 (UniProt, ExPASy) |
| UniProt Entry Name | MITF_HUMAN |
| Gene Symbol | MITF |
| KEGG | hsa:4286 |
| String | 9606.ENSP00000295600 |
| Molecular Weight | Calculated MW: 58.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat MITF. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |