Megakaryocytic Acute Leukemia Protein (MKL1) Antibody

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Target	Megakaryocytic Acute Leukemia Protein (MKL1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 497-525 amino acids from the Central region of human MKL1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q969V6 (UniProt, ExPASy)
UniProt Secondary AC	Q8TCL1, Q96SC5, Q96SC6, Q9P2B0
UniProt Entry Name	MRTFA_HUMAN
KEGG	hsa:57591
String	9606.ENSP00000347847
Molecular Weight	Calculated MW: 98.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Megakaryocytic Acute Leukemia Protein (MKL1)

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