DNA Mismatch Repair Protein Mlh1 (MLH1) Antibody

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined. This antibody is supplied as crude ascites.

Target	DNA Mismatch Repair Protein Mlh1 (MLH1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 458-489 amino acids from the Central region of human MLH1.
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Store at 2-8°C for up to 2 weeks, or for longer term, aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P40692 (UniProt, ExPASy)
UniProt Secondary AC	B4DI13, B4DQ11, E9PCU2
UniProt Entry Name	MLH1_HUMAN
Gene Symbol	MLH1
GeneID	4292
OMIM	114500
NCBI Accession	NP_000240.1 NM_000249.3
HGNC	7127
KEGG	hsa:4292
Ensembl	ENSG00000076242
String	9606.ENSP00000231790
Molecular Weight	Calculated MW: 84.6 kDa
Buffer	Ascites containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA Mismatch Repair Protein Mlh1 (MLH1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue