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DNA Mismatch Repair Protein Mlh1 (MLH1) Antibody
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Catalogue No: abx026385
Price:
US$326.25
(Size: 80 µl)
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This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
Research Articles on DNA Mismatch Repair Protein Mlh1 (MLH1)
| Target | DNA Mismatch Repair Protein Mlh1 (MLH1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 452-480 amino acids from the Central region of human MLH1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P40692 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DI13, B4DQ11, E9PCU2 |
| UniProt Entry Name | MLH1_HUMAN |
| Gene Symbol | MLH1 |
| GeneID | 4292 |
| OMIM | 114500 |
| NCBI Accession | NP_000240.1 NM_000249.3 |
| HGNC | 7127 |
| KEGG | hsa:4292 |
| Ensembl | ENSG00000076242 |
| String | 9606.ENSP00000231790 |
| Molecular Weight | Calculated MW: 84.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |