Matrix Metalloproteinase 14 (MMP14) Antibody

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Target	Matrix Metalloproteinase 14 (MMP14)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Mouse
Recommended dilutions	WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human MMP14.
Isotype	IgM
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P50281 (UniProt, ExPASy)
UniProt Secondary AC	A8K5L0, Q6GSF3, Q92678
UniProt Entry Name	MMP14_HUMAN
KEGG	hsa:4323
String	9606.ENSP00000308208
Molecular Weight	Calculated MW: 65.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow, Pig and Rabbit MMP14.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Matrix Metalloproteinase 14 (MMP14)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue