Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3) Antibody

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.

Target	Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 298-327 amino acids from the Central region of human MMP3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08254 (UniProt, ExPASy)
UniProt Secondary AC	B2R8B8, Q3B7S0, Q6GRF8
UniProt Entry Name	MMP3_HUMAN
KEGG	hsa:4314
String	9606.ENSP00000299855
Enzyme Commission Number	EC 3.4.24.17 EC 3.4.24
Molecular Weight	Calculated MW: 54 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3)

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