Mothers Against Decapentaplegic Homolog 2 (SMAD2) Antibody

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Catalogue No: abx011717
Price: US$406.00
(Size: 100 µg)

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Datasheet SDS
Mothers Against Decapentaplegic Homolog 2 (SMAD2) Antibody is a Rabbit Polyclonal antibody for the detection of SMAD2.

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF) -beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Target Mothers Against Decapentaplegic Homolog 2 (SMAD2)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen SMAD family member 2
Isotype IgG
Form Liquid
Purity ≥ 95% (SDS-PAGE)
Purification Purified by immunogen affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity 12 months.
UniProt Primary AC Q15796 (UniProt, ExPASy)
UniProt Entry Name SMAD2_HUMAN
Gene Symbol SMAD2
GeneID 4087
OMIM 601366
HGNC 6768
KEGG hsa:4087
Ensembl ENSG00000175387
String 9606.ENSP00000262160
Molecular Weight Observed MW: 52 kDa
Buffer PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration 2 mg/ml
Availability Shipped within 5-12 working days.
Note This product is for research use only.
Research Articles on Mothers Against Decapentaplegic Homolog 2 (SMAD2)


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