Mouse Irf3 Antibody

Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).

Target	Mouse Irf3
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P70671 (UniProt, ExPASy)
UniProt Entry Name	IRF3_MOUSE
KEGG	mmu:54131
String	10090.ENSMUSP00000003284
Molecular Weight	Calculated MW: 46.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow and Pig Irf3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mouse Irf3

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