+44 (0) 1223 755950
+1 832 327 7413
Mouse TSC2 (pS1412) Antibody
REQUEST MORE INFO
Catalogue No: abx032234
Price:
US$326.25
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
Research Articles on Mouse TSC2 (pS1412)
| Target | Mouse TSC2 (pS1412) |
| Clonality | Polyclonal |
| Target Modification | Ser1412 |
| Modification | Phosphorylation |
| Reactivity | Mouse |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1412 of mouse TSC2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q61037 (UniProt, ExPASy) |
| UniProt Secondary AC | P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6 |
| UniProt Entry Name | TSC2_MOUSE |
| String | 10090.ENSMUSP00000094986 |
| Molecular Weight | Calculated MW: 202 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |