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Thrombopoietin Receptor / CD110 (MPL) Antibody
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Catalogue No: abx011224
Price:
US$427.75
(Size: 100 µl)
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In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Research Articles on Thrombopoietin Receptor / CD110 (MPL)
| Target | Thrombopoietin Receptor / CD110 (MPL) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human MPL expressed in E. coli. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P40238 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5JUZ0 |
| UniProt Entry Name | TPOR_HUMAN |
| Gene Symbol | MPL |
| GeneID | 4352 |
| OMIM | 159530 |
| HGNC | 7217 |
| KEGG | hsa:4352 |
| Ensembl | ENSG00000117400 |
| String | 9606.ENSP00000361548 |
| Molecular Weight | 71.2 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
