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Double-Strand Break Repair Protein MRE11 (MRE11) Antibody
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Catalogue No: abx001996
Price:
US$348.00
(Size: 60 µl)
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MRE11 Antibody is a Rabbit Polyclonal antibody against MRE11. This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Research Articles on Double-Strand Break Repair Protein MRE11 (MRE11)
| Target | Double-Strand Break Repair Protein MRE11 (MRE11) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human MRE11A |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P49959 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KTC7, O43475 |
| UniProt Entry Name | MRE11_HUMAN |
| Gene Symbol | MRE11 |
| GeneID | 4361 |
| OMIM | 600814 |
| NCBI Accession | NP_005581.2 NM_005590.3 NP_005582.1 NM_005591.3 |
| KEGG | hsa:4361 |
| String | 9606.ENSP00000325863 |
| Molecular Weight | Calculated MW: 77 kDa/80 kDa/81 kDa Observed MW: 95 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
