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Myotubularin (MTM1) Antibody
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Catalogue No: abx033000
Price:
US$326.25
(Size: 80 µl)
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MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI (3) P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI (3) P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI (3) P.
Research Articles on Myotubularin (MTM1)
| Target | Myotubularin (MTM1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13496 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NDB1, B7Z491, F2Z330, Q8NEL1 |
| UniProt Entry Name | MTM1_HUMAN |
| KEGG | hsa:4534 |
| String | 9606.ENSP00000359423 |
| Molecular Weight | Calculated MW: 69.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |