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Serine/Threonine-Protein Kinase MTOR (MTOR) Antibody
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Catalogue No: abx032770
Price:
US$326.25
(Size: 80 µl)
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FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
Research Articles on Serine/Threonine-Protein Kinase MTOR (MTOR)
| Target | Serine/Threonine-Protein Kinase MTOR (MTOR) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 2459-2488 amino acids from human mTOR (FRAP1). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P42345 (UniProt, ExPASy) |
| UniProt Secondary AC | Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3 |
| UniProt Entry Name | MTOR_HUMAN |
| Gene Symbol | MTOR |
| KEGG | hsa:2475 |
| String | 9606.ENSP00000354558 |
| Molecular Weight | Calculated MW: 289 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat MTOR. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |