Serine/Threonine-Protein Kinase MTOR (MTOR) Antibody

FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.

Target	Serine/Threonine-Protein Kinase MTOR (MTOR)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 2459-2488 amino acids from human mTOR (FRAP1).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42345 (UniProt, ExPASy)
UniProt Secondary AC	Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3
UniProt Entry Name	MTOR_HUMAN
Gene Symbol	MTOR
KEGG	hsa:2475
String	9606.ENSP00000354558
Molecular Weight	Calculated MW: 289 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat MTOR.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serine/Threonine-Protein Kinase MTOR (MTOR)

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