Muscle Skeletal Receptor Tyrosine Kinase (MUSK) Antibody

MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

Target	Muscle Skeletal Receptor Tyrosine Kinase (MUSK)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O15146 (UniProt, ExPASy)
UniProt Secondary AC	Q32MJ8, Q32MJ9, Q5VZW7, Q5VZW8
Gene Symbol	MUSK
GeneID	4593
OMIM	208150
HGNC	7525
Ensembl	ENSG00000030304
Molecular Weight	97 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Muscle Skeletal Receptor Tyrosine Kinase (MUSK)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue