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Myc Proto-Oncogene Protein (MYC) Antibody
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Catalogue No: abx011213
Price:
US$406.00
(Size: 100 µg)
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Myc Proto-Oncogene Protein (MYC) Antibody is a Rabbit Polyclonal antibody for the detection of c-MYC. MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC.The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186]
Research Articles on Myc Proto-Oncogene Protein (MYC)
| Target | Myc Proto-Oncogene Protein (MYC) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | v-myc myelocytomatosis viral oncogene homolog(avian) |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P01106 (UniProt, ExPASy) |
| UniProt Secondary AC | A8WFE7, P01107, Q14026 |
| UniProt Entry Name | MYC_HUMAN |
| Gene Symbol | MYC |
| GeneID | 4609 |
| OMIM | 113970 |
| HGNC | 7553 |
| KEGG | hsa:4609 |
| Ensembl | ENSG00000136997 |
| String | 9606.ENSP00000479618 |
| Molecular Weight | Observed MW: 50-60 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |