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Myocilin (MYOC) Antibody
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Catalogue No: abx001338
Price:
US$348.00
(Size: 60 µl)
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MYOC Antibody is a Rabbit Polyclonal antibody against MYOC. Myocilin (MYOC), also known as TIGR or GLC1A, is a secreted glycoprotein of the olfactomedin family, originally identified in trabecular meshwork cells after prolonged treatment with glucocorticoids, and, independently, in the retina (PMID: 9176893; 9169133). It may participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma (POAG) (PMID: 21709622). MYOC has a molecular weight of 55-57 kDa, besides, a 66-kDa form, which could be a result of post-translational modifications, has also been reported in some researches (PMID: 9497363; 12150989).
Research Articles on Myocilin (MYOC)
| Target | Myocilin (MYOC) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human MYOC |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q99972 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RD84, O00620, Q7Z6Q9 |
| UniProt Entry Name | MYOC_HUMAN |
| Gene Symbol | MYOC |
| GeneID | 4653 |
| OMIM | 137750 |
| NCBI Accession | NP_000252.1 |
| HGNC | 7610 |
| KEGG | hsa:4653 |
| Ensembl | ENSG00000034971 |
| String | 9606.ENSP00000037502 |
| Molecular Weight | Calculated MW: 56 kDa Observed MW: 65 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |