Histone Acetyltransferase KAT8 (MYST1) Antibody

MYST1 (MYST histone acetyltransferase 1, MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone.

Target	Histone Acetyltransferase KAT8 (MYST1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human MYST1 expressed in E. coli.
Isotype	IgG2b
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9H7Z6 (UniProt, ExPASy)
UniProt Entry Name	KAT8_HUMAN
Gene Symbol	KAT8
GeneID	84148
OMIM	609912
HGNC	17933
Ensembl	ENSG00000103510
String	9606.ENSP00000406037
Enzyme Commission Number	EC 2.3.1.48
Molecular Weight	53 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Histone Acetyltransferase KAT8 (MYST1)

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