NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Target	NEDD8 Activating Enzyme E1 Subunit 1 (NAE1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 172-200 amino acids from the Central region of human NAE1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13564 (UniProt, ExPASy)
UniProt Secondary AC	A6NCK0, A6NFN4, A8MU28, B2R700, B3KUP9
UniProt Entry Name	ULA1_HUMAN
KEGG	hsa:8883
String	9606.ENSP00000351990
Molecular Weight	Calculated MW: 60.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat and Monkey NAE1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on NEDD8 Activating Enzyme E1 Subunit 1 (NAE1)

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