Neutrophil Cytosolic Factor 4 (NCF4) Antibody

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Catalogue No: abx033526
Price: US$326.25
(Size: 80 µl)

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Neutrophil Cytosolic Factor 4 (NCF4) Antibody
Neutrophil Cytosolic Factor 4 (NCF4) Antibody Neutrophil Cytosolic Factor 4 (NCF4) Antibody Neutrophil Cytosolic Factor 4 (NCF4) Antibody

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Datasheet SDS
NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI (3) kinase, which suggests its role in PI (3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity.

Target Neutrophil Cytosolic Factor 4 (NCF4)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC, FCM
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 260-289 amino acids from the C-terminal region of human NCF4.
Isotype IgG
Form Liquid
Purification Purified Rabbit Polyclonal Antibody.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15080 (UniProt, ExPASy)
UniProt Secondary AC A8K4F9, O60808, Q86U56, Q9BU98, Q9NP45
UniProt Entry Name NCF4_HUMAN
KEGG hsa:4689
String 9606.ENSP00000380334
Molecular Weight Calculated MW: 39 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Neutrophil Cytosolic Factor 4 (NCF4)
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