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Neutrophil Cytosolic Factor 4 (NCF4) Antibody
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Catalogue No: abx001708
Price:
US$348.00
(Size: 60 µl)
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NCF4 Antibody is a Rabbit Polyclonal antibody against NCF4. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Research Articles on Neutrophil Cytosolic Factor 4 (NCF4)
| Target | Neutrophil Cytosolic Factor 4 (NCF4) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human NCF4 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15080 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K4F9, O60808, Q86U56, Q9BU98, Q9NP45 |
| UniProt Entry Name | NCF4_HUMAN |
| Gene Symbol | NCF4 |
| GeneID | 4689 |
| NCBI Accession | NP_038202.2 |
| KEGG | hsa:4689 |
| String | 9606.ENSP00000380334 |
| Molecular Weight | Calculated MW: 39 kDa Observed MW: 40 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |