Nuclear Receptor Corepressor 1 (NCOR1) Antibody

NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. The gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.

Target	Nuclear Receptor Corepressor 1 (NCOR1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 16-47 amino acids from the N-terminal region of human NCOR1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75376 (UniProt, ExPASy)
UniProt Secondary AC	B3DLF8, E9PGV6, Q86YY0, Q9UPV5, Q9UQ18
UniProt Entry Name	NCOR1_HUMAN
KEGG	hsa:9611
String	9606.ENSP00000268712
Molecular Weight	Calculated MW: 270 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Nuclear Receptor Corepressor 1 (NCOR1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue