Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin (NEDD4) Antibody

NEDD4 Antibody is a Rabbit Polyclonal antibody against NEDD4. NEDD4-1(Neural precursor cell expressed developmentally down-regulated protein 4) is also named as NEDD4 and KIAA0093. It plays an essential role for the activation of the genetic program involved in the terminal maturation stage of invariant natural killer T-cell development(PMID:21949387). And it is differentially expressed in mammary epithelial cells and plays a role in luminal lineage determination(PMID:20351249). NEDD4-1 is a key regulator of FGFR1 endocytosis and signalling during neuronal differentiation and embryonic development(PMID:21765395). This antibody can recognize NEDD4-1 and NEDD4-2.

Target	Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin (NEDD4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 160-460 of human NEDD4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P46934 (UniProt, ExPASy)
UniProt Entry Name	NEDD4_HUMAN
Gene Symbol	NEDD4
GeneID	4734
NCBI Accession	NP_940682.2
KEGG	hsa:4734
String	9606.ENSP00000424827
Molecular Weight	Calculated MW: 149 kDa Observed MW: 120 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	2.61 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin (NEDD4)

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