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Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) Antibody
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Catalogue No: abx012321
Price:
US$420.50
(Size: 100 µl)
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Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
Research Articles on Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8)
| Target | Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human NEDD8 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15843 (UniProt, ExPASy) |
| UniProt Secondary AC | Q3SXN8, Q6LES6 |
| UniProt Entry Name | NEDD8_HUMAN |
| Gene Symbol | NEDD8 |
| GeneID | 4738 |
| OMIM | 603171 |
| HGNC | 7732 |
| KEGG | hsa:4738 |
| Ensembl | ENSG00000129559 |
| String | 9606.ENSP00000250495 |
| Molecular Weight | 9 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |