Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) Antibody

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Catalogue No: abx012321
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Target Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, IHC, IF/ICC, FCM
Host Mouse
Recommended dilutions ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human NEDD8 expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Purified from ascites by Protein G chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15843 (UniProt, ExPASy)
UniProt Secondary AC Q3SXN8, Q6LES6
UniProt Entry Name NEDD8_HUMAN
Gene Symbol NEDD8
GeneID 4738
OMIM 603171
HGNC 7732
KEGG hsa:4738
Ensembl ENSG00000129559
String 9606.ENSP00000250495
Molecular Weight 9 kDa
Buffer PBS, containing 0.05% sodium azide.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8)


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