Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) Antibody

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis.Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M.Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Target	Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human NEDD8 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15843 (UniProt, ExPASy)
UniProt Secondary AC	Q3SXN8, Q6LES6
UniProt Entry Name	NEDD8_HUMAN
Gene Symbol	NEDD8
GeneID	4738
OMIM	603171
HGNC	7732
KEGG	hsa:4738
Ensembl	ENSG00000129559
String	9606.ENSP00000250495
Molecular Weight	9 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8)

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