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Neurofilament, Light Polypeptide (NEFL) Antibody
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Catalogue No: abx011248
Price:
US$420.50
(Size: 100 µl)
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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Research Articles on Neurofilament, Light Polypeptide (NEFL)
| Target | Neurofilament, Light Polypeptide (NEFL) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human NEFL expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P07196 (UniProt, ExPASy) |
| UniProt Secondary AC | B9ZVN2, Q16154, Q8IU72 |
| UniProt Entry Name | NFL_HUMAN |
| Gene Symbol | NEFL |
| GeneID | 4747 |
| OMIM | 162280 |
| HGNC | 7739 |
| KEGG | hsa:4747 |
| Ensembl | ENSG00000277586 |
| String | 9606.ENSP00000482169 |
| Molecular Weight | 62 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |