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Nei Endonuclease VIII Like Protein 1 (NEIL1) Antibody
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Catalogue No: abx149860
Price:
US$406.00
(Size: 100 µg)
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Nei Endonuclease VIII Like Protein 1 (NEIL1) Antibody is a Rabbit Polyclonal antibody for the detection of NEIL1. Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'-and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Research Articles on Nei Endonuclease VIII Like Protein 1 (NEIL1)
| Target | Nei Endonuclease VIII Like Protein 1 (NEIL1) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | nei endonuclease VIII-like 1(E. coli) |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q96FI4 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DW75, Q6ZRA7, Q86XW7, Q9H6C3 |
| UniProt Entry Name | NEIL1_HUMAN |
| Gene Symbol | NEIL1 |
| GeneID | 79661 |
| OMIM | 608844 |
| HGNC | 18448 |
| KEGG | hsa:79661 |
| Ensembl | ENSG00000140398 |
| String | 9606.ENSP00000347170 |
| Molecular Weight | Observed MW: 44 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |