NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).
Target
Endonuclease 8-Like 2 (NEIL2)
Clonality
Polyclonal
Reactivity
Human
Tested Applications
ELISA, WB
Host
Rabbit
Recommended dilutions
WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation
Unconjugated
Immunogen
KLH-conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human NEIL2.
Isotype
IgG
Form
Liquid
Purification
Purified through a protein A column, followed by peptide affinity purification.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
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