NLR Family Pyrin Domain Containing 12 (NLRP12) Antibody

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.

Target	NLR Family Pyrin Domain Containing 12 (NLRP12)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 183-212 amino acids from the N-terminal region of human NLRP12.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P59046 (UniProt, ExPASy)
UniProt Secondary AC	A8MTQ2, B3KTE7, Q8NEU4, Q9BY26
UniProt Entry Name	NAL12_HUMAN
KEGG	hsa:91662
String	9606.ENSP00000375653
Molecular Weight	Calculated MW: 120 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on NLR Family Pyrin Domain Containing 12 (NLRP12)

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