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NACHT, LRR And PYD Domains-Containing Protein 3 (NLRP3) Antibody
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Catalogue No: abx004322
Price:
US$217.50
(Size: 20 µl)
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NLRP3 Antibody is a Rabbit Polyclonal antibody against NLRP3. This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
Research Articles on NACHT, LRR And PYD Domains-Containing Protein 3 (NLRP3)
| Target | NACHT, LRR And PYD Domains-Containing Protein 3 (NLRP3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/5000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 43-360 of human NLRP3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q96P20 (UniProt, ExPASy) |
| UniProt Entry Name | NLRP3_HUMAN |
| Gene Symbol | NLRP3 |
| GeneID | 114548 |
| NCBI Accession | NP_004886.3 |
| KEGG | hsa:114548 |
| String | 9606.ENSP00000337383 |
| Molecular Weight | Calculated MW: 118 kDa Observed MW: 85/110 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |