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NOS1 (pS1417) Antibody
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Catalogue No: abx032071
Price:
US$326.25
(Size: 80 µl)
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Three isoforms of nitric oxide synthase (NOS) have been identified. All are homodimers with subunits of 130-160 kDa. All have binding sites for NADPH, FAD, and FMN near the carboxyl terminus (the reductase domain), and binding sites for tetrahydrobiopterin (BH4) and heme near the amino terminus (the oxygenase domain). The reductase and oxygenase domains are linked by a calmodulin (CaM) binding site. Occupation of this site facilitates electron transfer from the cofactors in the reductase domain to heme during nitric oxide production. NOS catalyzes the conversion of arginine to citrulline and nitric oxide (NO). Neuronal nitric oxide synthase (NOS1, bNOS, cNOS, Type I) is associated with the post-synaptic density protein (PSD-95) in the neuronal membrane. In response to increased intracellular Ca2+, NOS1 interacts with CaM. The Ca2+ CaM complex, in combination with BH4, binds to NOS1 and induces its translocation from the plasma membrane to the cytoplasm. The dephosphorylation of NOS1 by calcineurin initiates the production NO. NO activates guanylyl cyclase (GC) and activates the various cGMP regulated signaling pathways. NOS1 is in activated by phosphorylation by protein kinase A (PKA) or protein kinase C (PKC).
Research Articles on NOS1 (pS1417)
| Target | NOS1 (pS1417) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | DB |
| Host | Rabbit |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1417 of human nNOS. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P29475 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PH30, O75713 |
| UniProt Entry Name | NOS1_HUMAN |
| KEGG | hsa:4842 |
| String | 9606.ENSP00000477999 |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |