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Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody
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Catalogue No: abx025429
Price:
US$326.25
(Size: 80 µl)
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This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].
Research Articles on Neurogenic Locus Notch Homolog Protein 3 (NOTCH3)
| Target | Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UM47 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9UEB3, Q9UPL3, Q9Y6L8 |
| UniProt Entry Name | NOTC3_HUMAN |
| String | 9606.ENSP00000263388 |
| Molecular Weight | Calculated MW: 244 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |