Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody
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Catalogue No: abx000900
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US$217.50
(Size: 20 µl)
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Datasheet SDS
NOTCH3 Antibody is a Rabbit Polyclonal antibody against NOTCH3. NOTCH3 belongs to the NOTCH family. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH3 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The antibody is specific to NOTCH3.
Research Articles on Neurogenic Locus Notch Homolog Protein 3 (NOTCH3)
| Target | Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) |
| Research Area | Signal Transduction |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to NOTCH3. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9UM47 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9UEB3, Q9UPL3, Q9Y6L8 |
| UniProt Entry Name | NOTC3_HUMAN |
| Gene Symbol | NOTCH3 |
| GeneID | 4854 |
| NCBI Accession | NP_000426.2 |
| String | 9606.ENSP00000263388 |
| Molecular Weight | Calculated MW: 244 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 3.36 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |