Oxysterols Receptor LXR-Alpha (NR1H3) Antibody

NR1H3 form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements.

Target	Oxysterols Receptor LXR-Alpha (NR1H3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 226-253 amino acids from the Central region of human NR1H3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13133 (UniProt, ExPASy)
UniProt Secondary AC	A8K3J9, D3DQR1, Q8IW13, Q96H87
UniProt Entry Name	NR1H3_HUMAN
KEGG	hsa:10062
String	9606.ENSP00000477707
Molecular Weight	Calculated MW: 50.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Oxysterols Receptor LXR-Alpha (NR1H3)

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