Neuregulin 1 (NRG1) Antibody

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Catalogue No: abx032738
Price: US$326.25
(Size: 80 µl)

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Neuregulin 1 (NRG1) Antibody
Neuregulin 1 (NRG1) Antibody Neuregulin 1 (NRG1) Antibody Neuregulin 1 (NRG1) Antibody

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Datasheet SDS
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

Target Neuregulin 1 (NRG1)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, IHC, FCM
Host Rabbit
Recommended dilutions IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 198-229 amino acids from the Central region of human NRG1.
Isotype IgG
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q02297 (UniProt, ExPASy)
NCBI Accession NP_001153467.1 NP_001153471.1 NP_001153473.1 NP_001153477.1 NP_001153480.1 NP_039250.2 NP_039251.2 NP_039252.2 NP_039253.1 NP_039254.1 NP_039256.2 NP_039258.1
Molecular Weight Calculated MW: 70.4 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Neuregulin 1 (NRG1)
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