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Neuregulin 3 (NRG3) Antibody
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Catalogue No: abx032740
Price:
US$326.25
(Size: 80 µl)
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NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.
Research Articles on Neuregulin 3 (NRG3)
| Target | Neuregulin 3 (NRG3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 305-336 amino acids from the Central region of human NRG3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P56975 (UniProt, ExPASy) |
| UniProt Secondary AC | A4D7U1, Q0PEH2, Q5VYH3 |
| UniProt Entry Name | NRG3_HUMAN |
| NCBI Accession | NP_001010848.2 NP_001159445.1 |
| KEGG | hsa:10718 |
| String | 9606.ENSP00000361214 |
| Molecular Weight | Calculated MW: 77.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse NRG3. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |