Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) Antibody

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

Target	Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant extracellular fragment of human NTRK3 (32-429 AA) fused with hIgGFc tag expressed in HEK293 cells.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q16288 (UniProt, ExPASy)
UniProt Secondary AC	B7Z4C5, E9PG56, H0YND1, O75682, Q12827, Q16289
UniProt Entry Name	NTRK3_HUMAN
Gene Symbol	NTRK3
GeneID	4916
OMIM	191316
HGNC	8033
KEGG	hsa:4916
Ensembl	ENSG00000140538
String	9606.ENSP00000354207
Enzyme Commission Number	EC 2.7.10.1
Molecular Weight	94 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3)

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