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Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1) Antibody
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Catalogue No: abx240011
Price:
US$406.00
(Size: 100 µg)
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Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1) Antibody is a Mouse Monoclonal antibody for the detection of NFKB1. This gene encodes a 105 kDa protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kDa protein. The 105 kDa protein is a Rel protein-specific transcription inhibitor and the 50 kDa protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
Research Articles on Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1)
| Target | Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/3000, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Isotype | IgG2a |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P19838 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K5Y5, B3KVE8, Q68D84, Q86V43, Q8N4X7, Q9NZC0 |
| UniProt Entry Name | NFKB1_HUMAN |
| Gene Symbol | NFKB1 |
| GeneID | 4790 |
| OMIM | 164011 |
| HGNC | 7794 |
| KEGG | hsa:4790 |
| Ensembl | ENSG00000109320 |
| String | 9606.ENSP00000226574 |
| Molecular Weight | Observed MW: 105 kDa/50 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |