Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1) Antibody

Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1) Antibody is a Mouse Monoclonal antibody for the detection of NFKB1.

This gene encodes a 105 kDa protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kDa protein. The 105 kDa protein is a Rel protein-specific transcription inhibitor and the 50 kDa protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

Target	Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/3000, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Isotype	IgG2a
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P19838 (UniProt, ExPASy)
UniProt Secondary AC	A8K5Y5, B3KVE8, Q68D84, Q86V43, Q8N4X7, Q9NZC0
UniProt Entry Name	NFKB1_HUMAN
Gene Symbol	NFKB1
GeneID	4790
OMIM	164011
HGNC	7794
KEGG	hsa:4790
Ensembl	ENSG00000109320
String	9606.ENSP00000226574
Molecular Weight	Observed MW: 105 kDa/50 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Nuclear Factor NF-Kappa-B P105 Subunit (NFKB1)

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