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2'-5'-Oligoadenylate Synthase-Like Protein (OASL) Antibody
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Catalogue No: abx032744
Price:
US$326.25
(Size: 80 µl)
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2-prime, 5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
Research Articles on 2'-5'-Oligoadenylate Synthase-Like Protein (OASL)
| Target | 2'-5'-Oligoadenylate Synthase-Like Protein (OASL) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 484-514 amino acids from the C-terminal region of human OASL. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15646 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RAZ2, I1YDD2, O75686, Q17R95, Q9Y6K6, Q9Y6K7 |
| UniProt Entry Name | OASL_HUMAN |
| Gene Symbol | OASL |
| GeneID | 8638 |
| OMIM | 603281 |
| NCBI Accession | NP_001248754.1 NP_003724.1 NP_937856.1 |
| HGNC | 8090 |
| KEGG | hsa:8638 |
| Ensembl | ENST00000257570.9 |
| String | 9606.ENSP00000257570 |
| Molecular Weight | Calculated MW: 59.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |