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POU Class 5 Homeobox 1 / OCT4 (POU5F1) Antibody
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Catalogue No: abx016043
Price:
US$420.50
(Size: 100 µl)
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Oct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, also known as POU5F1 (POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment.Entrez Protein NP_002692.Oct-3/4 sustains stem-cell selfrenewal and differentiation pathways.Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development.Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene.In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells.Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.
Research Articles on POU Class 5 Homeobox 1 / OCT4 (POU5F1)
| Target | POU Class 5 Homeobox 1 / OCT4 (POU5F1) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of Oct4 (aa193-360) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q01860 (UniProt, ExPASy) |
| UniProt Entry Name | PO5F1_HUMAN |
| Gene Symbol | POU5F1 |
| GeneID | 5460 |
| OMIM | 164177 |
| HGNC | 9221 |
| KEGG | hsa:5460 |
| Ensembl | ENSG00000204531 |
| String | 9606.ENSP00000259915 |
| Molecular Weight | 38.5 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |