Oligodendrocyte Transcription Factor 2 (OLIG2) Antibody

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain.The protein is an essential regulator of ventral neuroectodermal progenitor cell fate.The gene is involved in a chromosomal translocation t (14;21) (q11.2;q22) associated with T-cell acute lymphoblastic leukemia.Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.Tissue specificity: Expressed in the brain, in oligodendrocytes.Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas.Expression in glioblastomas highly variable.

Target	Oligodendrocyte Transcription Factor 2 (OLIG2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human OLIG2 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID	10215
Molecular Weight	32 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Oligodendrocyte Transcription Factor 2 (OLIG2)

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