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Osteocalcin (BGLAP) Antibody
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Catalogue No: abx031339
Price:
US$326.25
(Size: 80 µl)
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Prior to the formation of calcified bone, noncollagenous Proteins form in the extracellular bone matrix. Gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding Proteins containing residues of Gla. These residues are essential for the binding of calcium and constitue 1-2% of total bone Protein. Osteocalcin (BGLAP) itself binds strongly to apatite and calcium. Production of Osteocalcin (BGLAP) is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular Osteocalcin (BGLAP) production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further Osteocalcin (BGLAP) production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of Osteocalcin (BGLAP) production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.
Research Articles on Osteocalcin (BGLAP)
| Target | Osteocalcin (BGLAP) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Osteocalcin. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P02818 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5TCK6 |
| UniProt Entry Name | OSTCN_HUMAN |
| Gene Symbol | BGLAP |
| GeneID | 632 |
| OMIM | 112260 |
| NCBI Accession | NP_954642.1 |
| HGNC | 1043 |
| KEGG | hsa:632 |
| Ensembl | ENSG00000242252 |
| String | 9606.ENSP00000357255 |
| Molecular Weight | Calculated MW: 11 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |