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ATP-Dependent Translocase ABCB1 (ABCB1) Antibody
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Catalogue No: abx149070
Price:
US$406.00
(Size: 100 µg)
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ATP-Dependent Translocase ABCB1 (ABCB1) Antibody is a Rabbit Polyclonal antibody for the detection of P Glycoprotein. ABCB1 (also known as P-gp/ P-glycoprotein, MDR1/multidrug-resistance 1) is a plasma membrane protein first discovered in multidrug resistant tumor cells. ABCB1 can extrude a large number of medically relevant compounds from cells and causes drug resistance. ABCB1 is expressed in a variety of human cancers as well as normal tissues including brain, and placenta. Overexpression of ABCB1 correlates with a negative prognosis in several types of cancer.
Research Articles on ATP-Dependent Translocase ABCB1 (ABCB1)
| Target | ATP-Dependent Translocase ABCB1 (ABCB1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/1000, IHC: 1/50 - 1/500, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | ABCB1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P08183 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K294, B5AK60, Q12755, Q14812 |
| UniProt Entry Name | MDR1_HUMAN |
| Gene Symbol | ABCB1 |
| GeneID | 5243 |
| OMIM | 171050 |
| HGNC | 40 |
| KEGG | hsa:5243 |
| Ensembl | ENSG00000085563 |
| String | 9606.ENSP00000478255 |
| Molecular Weight | Observed MW: 142 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |