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Cyclin-Dependent Kinase Inhibitor 2A / P16-INK4A Antibody
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Catalogue No: abx236064
Price:
US$406.00
(Size: 100 µg)
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CDKN2A / P16-INK4A Antibody is a Rabbit Polyclonal against CDKN2A. CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, and two are related, named p16-INK4 and p14 respetively, sharing 50% identity. The third one is completely stuctually un-related, called p14(ARF) or p19(ARF). This antibody reacts with p16 specifically. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.
Research Articles on Cyclin-Dependent Kinase Inhibitor 2A
| Target | Cyclin-Dependent Kinase Inhibitor 2A |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/5000, IHC: 1/50 - 1/500, IF/ICC: 1/20 - 1/200, IP: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, p16, inhibits CDK4) |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P42771 (UniProt, ExPASy) |
| UniProt Entry Name | CDN2A_HUMAN |
| GeneID | 1029 |
| NCBI Accession | NP_000068.1 |
| KEGG | hsa:1029 |
| String | 9606.ENSP00000418915 |
| Molecular Weight | Observed MW: 16-18 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |