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Cell Division Cycle 20 (CDC20) Antibody
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Catalogue No: abx148978
Price:
US$406.00
(Size: 100 µg)
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Cell Division Cycle 20 (CDC20) Antibody is a Rabbit Polyclonal antibody for the detection of Cdc20. Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Research Articles on Cell Division Cycle 20 (CDC20)
| Target | Cell Division Cycle 20 (CDC20) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | cell division cycle 20 homolog |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q12834 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6Z6, D3DPJ1, Q5JUY4, Q9BW56, Q9UQI9 |
| UniProt Entry Name | CDC20_HUMAN |
| Gene Symbol | CDC20 |
| GeneID | 991 |
| OMIM | 603618 |
| HGNC | 1723 |
| KEGG | hsa:991 |
| Ensembl | ENSG00000117399 |
| String | 9606.ENSP00000361540 |
| Molecular Weight | Observed MW: 55 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |