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Polyadenylate-Binding Protein 2 (PABPN1) Antibody
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Catalogue No: abx029099
Price:
US$326.25
(Size: 80 µl)
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This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly (A) tails. The protein is required for progressive and efficient polymerization of poly (A) tails on the 3' ends of eukaryotic genes and controls the size of the poly (A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly (A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.
Research Articles on Polyadenylate-Binding Protein 2 (PABPN1)
| Target | Polyadenylate-Binding Protein 2 (PABPN1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 270-298 amino acids from the C-terminal region of human PABPN1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q86U42 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DS49, O43484 |
| UniProt Entry Name | PABP2_HUMAN |
| Gene Symbol | PABPN1 |
| KEGG | hsa:8106 |
| String | 9606.ENSP00000216727 |
| Molecular Weight | Calculated MW: 32.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Cow PABPN1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |