Multifunctional Protein ADE2H1 (PAICS) Antibody

This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Target	Multifunctional Protein ADE2H1 (PAICS)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 95-123 amino acids from the N-terminal region of human PAICS.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P22234 (UniProt, ExPASy)
UniProt Secondary AC	E9PDH9, Q68CQ5
UniProt Entry Name	PUR6_HUMAN
Gene Symbol	PAICS
KEGG	hsa:10606
String	9606.ENSP00000382595
Molecular Weight	Calculated MW: 47.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Chicken PAICS.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Multifunctional Protein ADE2H1 (PAICS)

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