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Leucine-Rich Repeat Serine/threonine-Protein Kinase 2 (PARK8) Antibody
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Catalogue No: abx033176
Price:
US$326.25
(Size: 80 µl)
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Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
Research Articles on Leucine-Rich Repeat Serine/threonine-Protein Kinase 2 (PARK8)
| Target | Leucine-Rich Repeat Serine/threonine-Protein Kinase 2 (PARK8) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 931-962 amino acids from human PARK8 (LRRK2). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q5S007 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NJU2, Q6ZS50, Q8NCX9 |
| UniProt Entry Name | LRRK2_HUMAN |
| NCBI Accession | NP_940980.3 |
| KEGG | hsa:120892 |
| String | 9606.ENSP00000298910 |
| Molecular Weight | Calculated MW: 286 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |