PARP1 (pS177) Antibody

This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Target	PARP1 (pS177)
Clonality	Polyclonal
Target Modification	Ser177
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S177 of human PARP1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P09874 (UniProt, ExPASy)
UniProt Secondary AC	B1ANJ4, Q8IUZ9
UniProt Entry Name	PARP1_HUMAN
KEGG	hsa:142
String	9606.ENSP00000355759
Molecular Weight	Calculated MW: 113 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Hamster PARP1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on PARP1 (pS177)

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