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Protein Patched Homolog 1 (PTCH1) Antibody
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Catalogue No: abx011414
Price:
US$406.00
(Size: 100 µg)
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Protein Patched Homolog 1 (PTCH1) Antibody is a Rabbit Polyclonal antibody for the detection of PTCH1. Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Research Articles on Protein Patched Homolog 1 (PTCH1)
| Target | Protein Patched Homolog 1 (PTCH1) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | patched homolog 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q13635 (UniProt, ExPASy) |
| UniProt Entry Name | PTC1_HUMAN |
| Gene Symbol | PTCH1 |
| GeneID | 5727 |
| OMIM | 109400 |
| HGNC | 9585 |
| KEGG | hsa:5727 |
| Ensembl | ENSG00000185920 |
| String | 9606.ENSP00000332353 |
| Molecular Weight | Observed MW: 161 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |