+44 (0) 1223 755950
+1 832 327 7413
Paired Box Protein Pax-5 (PAX5) Antibody
REQUEST MORE INFO
Catalogue No: abx012139
Price:
US$427.75
(Size: 100 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t (9;14) (p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. References 1.Cancer Res. 2011 Dec 15;71 (24):7345-50. 2.Am J Clin Pathol. 2010 Jan;133 (1):41-8. Related Products.
Research Articles on Paired Box Protein Pax-5 (PAX5)
| Target | Paired Box Protein Pax-5 (PAX5) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q02548 (UniProt, ExPASy) |
| UniProt Entry Name | PAX5_HUMAN |
| Gene Symbol | PAX5 |
| GeneID | 5079 |
| OMIM | 167414 |
| HGNC | 8619 |
| KEGG | hsa:5079 |
| Ensembl | ENSG00000196092 |
| String | 9606.ENSP00000350844 |
| Molecular Weight | 45 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |